[cevdroga] ..Gene Mutation that Regulates Sensitivity to Alcohol

Laercio Elias Pereira laercio em cev.org.br
Domingo Outubro 8 19:15:57 BRT 2006


Coordenadora Liana, Pessoal,
    Acho otimo ampliar esse debate
sobra a adiccao como uma doenca.
Acabo de receber um telefonema de
pais, professores em panico, que
nao sabem nisso e, pior, nao tem
a informacao de que a saida (provavelmente
a unica) Sao os grupos de ajuda familiar,
como Nar-Anos e Amorexigente! Devia
ter esse conhecimento na escola!

 Andrea ta' caminhando na direcao desse
artigo, com o Dr. dela de Genetica nessa
direcao. Ela e' biologa. Dirige a cevgenetica e
esta' contando com o apoio do COI.
    Ha' esperanca!
    Laercio

PS: Tb precisamos juntar bibliografia sobre
drogas e esporte (especialmente esporte
na escola). A turma da lista de Lazer ja' esta'
em campo juntando a bibliografia deles:
http://www.cev.org.br/br/listas/listas.asp?cd_lista=53

2006/10/8, Liana Romera <liromera em uol.com.br>:
> Olá Laércio, obrigada pela enorme contribuiçaão à lista. Descobertas como
> está reafirmam que cmportamentos de dependência, como este de  sensibilidade
> ao álcool  caracteriza-se por uma doença, e não mais simplesmente  um
> "comportamento", fato que atribuía a responsabilidade da reversão do quadro
> unicamente ao usuário, na verdade, um pacienteParece um assunto interessante
> para provocar um debate, o que acha??
> Abraço, Liana
> ----- Original Message -----
> From: "Laercio Elias Pereira" <laercio em cev.org.br>
> To: "Tocadores de Listas do CEV" <admincev em listas.cev.org.br>; "Genetica e
> Esporte" <cevgenetica em listas.cev.org.br>; "Drogas e Atividade Fisica"
> <cevdroga em listas.cev.org.br>; "Psicologia do Esporte"
> <cevpsi em listas.cev.org.br>
> Sent: Sunday, October 08, 2006 2:58 PM
> Subject: [cevdroga] ..Gene Mutation that Regulates Sensitivity to Alcohol
>
>
> psi - Laercio
> ...............
> "David P. Dillard" <jwne em temple.edu>  Adicionar endereço
> Data: Sun, 8 Oct 2006
> Assunto: [Net-Gold] BIOLOGY: RESEARCH: Fruit Fly Study Identifies Gene
> Mutation that Regulates Sensitivity to Alcohol
>
> U.S. Department of Health and Human Services
> NATIONAL INSTITUTES OF HEALTH
> NIH News
>
> National Institute on Alcohol Abuse and Alcoholism (NIAAA)
> <http://www.niaaa. nih.gov/>
>
> EMBARGOED FOR RELEASE: Thursday, October 5, 2006, 12:00 Noon ET
> CONTACT: NIAAA Press Office, 301-443-3860, <greg.roa em nih. gov>,
> FRUIT FLY STUDY IDENTIFIES GENE MUTATION THAT REGULATES SENSITIVITY TO
> ALCOHOL
>
> Researchers at the University of California, San Francisco (UCSF) have
> discovered a gene mutation in fruit flies that alters sensitivity to
> alcohol. The findings, reported in the October 6 issue of the journal
> "Cell", may have implications for human studies seeking to understand
> innate differences in people's tolerance for alcohol. The research was
> supported by the National Institute on Alcohol Abuse and Alcoholism
> (NIAAA) and the National Institute on Drug Abuse (NIDA) of the National
> Institutes of Health (NIH), part of the U.S. Department of Health and
> Human Services.
>
> The study was authored by Adrian Rothenfluh, Ph.D., and colleagues in
> the laboratory of Ulrike Heberlein, Ph.D., at UCSF, in collaboration
> with researchers at the Ernest Gallo Clinic & Research Center. The
> scientists examined the behavior of fruit flies (Drosophila) exposed to
> alcohol. Ordinarily, at low doses of alcohol fruit flies increase their
> activity, while high doses have a sedative effect. However, the
> researchers found some fruit flies were much more resistant to alcohol
> sedation. These flies continued to move about much longer than typical
> fruit flies exposed to the same amount of alcohol. The scientists
> subsequently identified key differences in a particular gene associated
> with this behavior. The mutation also altered the flies' sensitivity to
> cocaine and nicotine as well. Because this gene variant affected the
> behavioral response to substances of abuse, the researchers dubbed it
> white rabbit -- a reference to the title of a 1960s song about
> drug-induced changes.
>
> "This study describes key molecular pathways and gene interactions that
> control alcohol sensitivity, " said NIAAA Director Ting-Kai Li, M.D.
> "These significant clues about the fruit fly's behavioral response may
> translate into useful tools to advance the search for human genes
> involved in sensitivity to alcohol. Insights about sensitivity, or acute
> tolerance, are especially important because we know that people who are
> less sensitive to alcohol's impact are at greater risk for becoming
> alcohol dependent," he said.
>
> The researchers exposed fruit flies to vaporized alcohol and monitored
> their behavior and motion patterns with sensitive tracking instruments.
> They isolated the flies that were less sensitive to alcohol's sedative
> effects. By breeding subsequent populations of mutant flies, the
> scientists identified the particular genetic mutation.
>
> The researchers further showed that the white rabbit mutation disrupted
> the function of the RhoGAP18B gene. They also isolated a number of gene
> variants of RhoGAP18B, each of which had a distinctly different effect
> on the response to alcohol. Manipulating these genetic variants, the
> researchers generated flies with greater and lesser sensitivity to
> alcohol's sedative and stimulant effects.
>
> The research team also detailed how signaling proteins encoded by the
> RhoGAP18B gene variants played an important role in reorganizing
> components of the adult fruit fly's central nervous system, which in
> turn affected the flies' behavior. Dr. Rothenfluh said the research
> team concluded that the "RhoGAP18B" gene is intimately involved in
> regulating behavioral responses to alcohol exposure.
>
> The findings have implications for researchers seeking corresponding
> genes and molecular pathways in other animal models and humans. Antonio
> Noronha, Ph.D., director of NIAAA's Division of Neuroscience and
> Behavior, said, "If we can characterize similar genetic differences and
> neurobehavioral responses that underlie acute tolerance in humans, that
> could potentially provide new targets for the development of drugs to
> treat alcohol dependence."
>
> NIAAA is the primary U.S. agency for conducting and supporting research
> on the causes, consequences, prevention, and treatment of alcohol abuse,
> alcoholism, and alcohol problems and disseminates research findings to
> general, professional, and academic audiences. Additional alcohol
> research information and publications are available at
>
> <http://www.niaaa. nih.gov>
>
> The National Institutes of Health (NIH) -- "The Nation's Medical
> Research Agency" -- includes 27 Institutes and Centers and is a
> component of the U.S. Department of Health and Human Services. It is the
> primary federal agency for conducting and supporting basic, clinical and
> translational medical research, and it investigates the causes,
> treatments, and cures for both common and rare diseases. For more
> information about NIH and its programs, visit
>
> <http://www.nih. gov>.
>
>
>
> --
> Laercio Elias Pereira
> http://www.cev.org.br/grcev/laercio
> Receba(quinzenalmente) as novidades do CEV
> http://www.cev.org.br/br/novidades/
> _______________________________________________
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>
> Receba(quinzenalmente) as novidades do CEV  http://www.cev.org.br/br/novidades/
> _______________________________________________
> Lista cevdroga Adm: liana em cev.org.br
> SAIR DA LISTA/OUTRAS OPÇÕES
> http://www.cev.org.br/br/listas/listas.asp?cd_listax
>


-- 
Laercio Elias Pereira
http://www.cev.org.br/grcev/laercio



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