[cevdroga] ..Gene Mutation that Regulates Sensitivity to Alcohol

Liana Romera liromera em uol.com.br
Domingo Outubro 8 18:26:43 BRT 2006

Olá Laércio, obrigada pela enorme contribuiçaão à lista. Descobertas como 
está reafirmam que cmportamentos de dependência, como este de  sensibilidade 
ao álcool  caracteriza-se por uma doença, e não mais simplesmente  um 
"comportamento", fato que atribuía a responsabilidade da reversão do quadro 
unicamente ao usuário, na verdade, um pacienteParece um assunto interessante 
para provocar um debate, o que acha??
Abraço, Liana
----- Original Message ----- 
From: "Laercio Elias Pereira" <laercio em cev.org.br>
To: "Tocadores de Listas do CEV" <admincev em listas.cev.org.br>; "Genetica e 
Esporte" <cevgenetica em listas.cev.org.br>; "Drogas e Atividade Fisica" 
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Sent: Sunday, October 08, 2006 2:58 PM
Subject: [cevdroga] ..Gene Mutation that Regulates Sensitivity to Alcohol

psi - Laercio
"David P. Dillard" <jwne em temple.edu>  Adicionar endereço
Data: Sun, 8 Oct 2006
Assunto: [Net-Gold] BIOLOGY: RESEARCH: Fruit Fly Study Identifies Gene
Mutation that Regulates Sensitivity to Alcohol

U.S. Department of Health and Human Services
NIH News

National Institute on Alcohol Abuse and Alcoholism (NIAAA)
<http://www.niaaa. nih.gov/>

EMBARGOED FOR RELEASE: Thursday, October 5, 2006, 12:00 Noon ET
CONTACT: NIAAA Press Office, 301-443-3860, <greg.roa em nih. gov>,

Researchers at the University of California, San Francisco (UCSF) have
discovered a gene mutation in fruit flies that alters sensitivity to
alcohol. The findings, reported in the October 6 issue of the journal
"Cell", may have implications for human studies seeking to understand
innate differences in people's tolerance for alcohol. The research was
supported by the National Institute on Alcohol Abuse and Alcoholism
(NIAAA) and the National Institute on Drug Abuse (NIDA) of the National
Institutes of Health (NIH), part of the U.S. Department of Health and
Human Services.

The study was authored by Adrian Rothenfluh, Ph.D., and colleagues in
the laboratory of Ulrike Heberlein, Ph.D., at UCSF, in collaboration
with researchers at the Ernest Gallo Clinic & Research Center. The
scientists examined the behavior of fruit flies (Drosophila) exposed to
alcohol. Ordinarily, at low doses of alcohol fruit flies increase their
activity, while high doses have a sedative effect. However, the
researchers found some fruit flies were much more resistant to alcohol
sedation. These flies continued to move about much longer than typical
fruit flies exposed to the same amount of alcohol. The scientists
subsequently identified key differences in a particular gene associated
with this behavior. The mutation also altered the flies' sensitivity to
cocaine and nicotine as well. Because this gene variant affected the
behavioral response to substances of abuse, the researchers dubbed it
white rabbit -- a reference to the title of a 1960s song about
drug-induced changes.

"This study describes key molecular pathways and gene interactions that
control alcohol sensitivity, " said NIAAA Director Ting-Kai Li, M.D.
"These significant clues about the fruit fly's behavioral response may
translate into useful tools to advance the search for human genes
involved in sensitivity to alcohol. Insights about sensitivity, or acute
tolerance, are especially important because we know that people who are
less sensitive to alcohol's impact are at greater risk for becoming
alcohol dependent," he said.

The researchers exposed fruit flies to vaporized alcohol and monitored
their behavior and motion patterns with sensitive tracking instruments.
They isolated the flies that were less sensitive to alcohol's sedative
effects. By breeding subsequent populations of mutant flies, the
scientists identified the particular genetic mutation.

The researchers further showed that the white rabbit mutation disrupted
the function of the RhoGAP18B gene. They also isolated a number of gene
variants of RhoGAP18B, each of which had a distinctly different effect
on the response to alcohol. Manipulating these genetic variants, the
researchers generated flies with greater and lesser sensitivity to
alcohol's sedative and stimulant effects.

The research team also detailed how signaling proteins encoded by the
RhoGAP18B gene variants played an important role in reorganizing
components of the adult fruit fly's central nervous system, which in
turn affected the flies' behavior. Dr. Rothenfluh said the research
team concluded that the "RhoGAP18B" gene is intimately involved in
regulating behavioral responses to alcohol exposure.

The findings have implications for researchers seeking corresponding
genes and molecular pathways in other animal models and humans. Antonio
Noronha, Ph.D., director of NIAAA's Division of Neuroscience and
Behavior, said, "If we can characterize similar genetic differences and
neurobehavioral responses that underlie acute tolerance in humans, that
could potentially provide new targets for the development of drugs to
treat alcohol dependence."

NIAAA is the primary U.S. agency for conducting and supporting research
on the causes, consequences, prevention, and treatment of alcohol abuse,
alcoholism, and alcohol problems and disseminates research findings to
general, professional, and academic audiences. Additional alcohol
research information and publications are available at

<http://www.niaaa. nih.gov>

The National Institutes of Health (NIH) -- "The Nation's Medical
Research Agency" -- includes 27 Institutes and Centers and is a
component of the U.S. Department of Health and Human Services. It is the
primary federal agency for conducting and supporting basic, clinical and
translational medical research, and it investigates the causes,
treatments, and cures for both common and rare diseases. For more
information about NIH and its programs, visit

<http://www.nih. gov>.

Laercio Elias Pereira
Receba(quinzenalmente) as novidades do CEV 
Lista cevdroga Adm: liana em cev.org.br

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